Manuscripts in Preparation
Terence Gall-Duncan*, Sangyoon Y. Ko*, Isabelle K. Quick*, Mahreen Khan, Kristie Feng, Chase P. Kelley, Annabelle Coleman, Alexiane Touze, Shuqian Tang, Mustafa Mehkary, Katsuyuki Yokoi, Casey R. Herrington, Justin You, Scott C. Lambie, Tanya K. Prasolava, Gagan B. Panigrahi, Jeehye Park, Kazuhiko Nakatani, Lauren M. Byrne, Peixiang Wang, John S. Schneekloth Jr., Masayuki Nakamori, Paul W. Frankland, Eric T. Wang, Christopher E Pearson#. Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence. Under review at Nature Genetics (bioRxiv, https://doi.org/10.1101/2025.04.25.650652).
Sangyoon Y. Ko, Stephen F. Pastore, Jonathan R. Epp, Anna Mikhailov, Leon French, Hidekiyo Harada, Philippe P. Monnier, Paul A. Hamel, Sheena A. Josselyn, John B. Vincent#, Paul W. Frankland#. Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication. Under review at Molecular Psychiatry.
Peer-Reviewed Publications
- Clarrisa A. Bradley, Sangyoon Y. Ko, Meng Tian*, Liam T. Ralph*, Lia D’Abate, Jinyeol Lee, Tianyi Liu, Junhui Wang, Patrick Tidball, Marla Mendes, Xiaolian Fan, Jennifer L. Howe, Roumiana Alexandrova, Giovanna Pellecchia, Guillermo Casallo, Tara Paton, Leanne E. Wybenga-Groot, Worrawat Engchuan, Bhooma Thiruvahindrapuram, Brett Trost, Jill de Rijke, Ashish Kadia, Fuzi Jin, Nelson Bautista Salazar, J. Javier Diaz-Mejia, Jeffrey R. MacDonald, Eric Deneault, P. Joel Ross, James Ellis, Carole Shum, John Georgiou, Olivia Rennie, Miriam S. Reuter, Ny Hoang, Ege Sarikaya, Thanuja Selvanayagam, Aeen E. Amini, Annabel Rutherford, Natalia Rivera-Alfaro, Christian R. Marshall, Marcello Scala, Cassandra K. Runke, Hutton M. Kearney, John Christodoulou, David I. Francis, Brian H. Y. Chung, Jill Plucinicazak, Alana Iaboni, Kristen M. Wigby, Christine W. Nordahl, David G. Amaral, Melissa L. Hudson, Calvin P. Sjaarda, Andrea Guerin, Mayada Elsabbagh, Rebecca Landa, Seema Mital, Robert Lesurf, Anjali Jain, Michael D. Wilson, Jason P. Lerch, Leo J. Lee, Brendan J. Frey, Michael W. Salter, Jacob A.S Vorstman, Evdokia Anagnostou, Paul W. Frankland, Graham L. Collingridge, and Stephen W. Scherer#. An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism. Nature (accepted, 2026).
Sangyoon Y. Ko, Yiming Rong, Adam I. Ramsaran, Xiaoyu Chen, Asim J. Rashid, Andrew Mocle, Jagroop Dhaliwal, Ankit Awasthi, Axel Guskjolen, Sheena A. Josselyn, Paul W. Frankland# (2025). Systems consolidation reorganizes hippocampal engram circuitry. Nature, 643(8072), 735-743.
- We demonstrate that hippocampal engram circuits are dynamically reorganized during systems consolidation, transforming episodic memories into more generalized, gist-like representations.
- Marcello Scala#, Lisa Bradley, Jennifer Howe, Brett Trost, Nelson Bautista Salazar, Carole Shum, Miriam S. Reuter, Jeffrey R. MacDonald, Sangyoon Y. Ko, Paul W. Frankland, Leslie Granger, Verdiana Pullano, Alfredo Brusco, Roberto Keller, Sarah Parisotto, Helio Pedro, Laina Lusk, Annabelle Tuttle, Emilie Douine-Barthelemy, Bianca Russell, Federico Zara, Stephen W. Scherer# (2025). Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus. American Journal of Human Genetics, 112(1), 154-167.
- Sungmo Park, Sang Yoon Ko, Paul W. Frankland, Sheena A. Josselyn# (2024). Comparing behaviours induced by natural memory retrieval and optogenetic reactivation of an engram ensemble in mice. Philosophical Transactions of the Royal Society B, 379(1906), 20230227.
- Adam I. Ramsaran, Ying Wang, Ali Golbabaei, Stepan Aleshin, Mitchell L. de Snoo, Bi-ru Amy Yeung, Asim J. Rashid, Ankit Awasthi, Jocelyn Lau, Lina M. Tran, Sangyoon Y. Ko, Andrin Abbegg, Lana Chunan Duan, Cory McKenzie, Julia Gallucci, Moriam Ahmed, Rahul Kaushik, Alexander Dityatev, Sheena A. Josselyn, Paul W. Frankland# (2023). A shift in the mechanisms controlling hippocampal engram formation during brain maturation. Science, 380(6644), 543-551.
- Stephen F. Pastore, Sangyoon Y. Ko, Paul W. Frankland, Paul A. Hamel, John B. Vincent# (2022). PTCHD1: Discovery and neurodevelopmental contributions of an autism spectrum disorder and intellectual disability susceptibility gene. Genes, 13(3), 527.
- Sangyoon Y. Ko and Paul W. Frankland# (2021). Neurogenesis-dependent transformation of hippocampal engrams. Neuroscience Letters, 762, 136176.
- Young-Suk Choi*, Somang Kang*, Sang-Yoon Ko*, Saeram Lee, Jae Young Kim, Hansol Lee, Jae Eun Song, Dong-Hyun Kim, Eosu Kim, Chul Hoon Kim, Lisa Saksida, Ho-Taek Song#, Jong Eun Lee# (2018). Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet. Molecular brain,11, 1-12.
- Jia Bao Zhang, Sang-Yoon Ko, Yulan Liao, Yubeen Gwon, Se Jin Jeon, Dong Hyun Kim, Jong Hoon Ryu# (2018). Activation of the dopamine D1 receptor can extend long-term spatial memory persistence via PKA signaling in mice. Neurobiology of learning and memory, 155, 568-577.
- Jee Hyun Yi*, Jia Bao Zhang*, Sang Yoon Ko, Huiyoung Kwon, Se Jin Jeon, Se Jin Park, Jiwook Jung, Byung C. Kim, Dong Hyun Kim#, Jong Hoon Ryu# (2018). Fluoxetine inhibits natural decay of long-term memory via Akt/GSK-3b signaling. Molecular neurobiology, 55, 7453-7462.
- Hyung Eun Lee, Se Jin Jeon, Byeol Ryu, Se Jin Park, Sang Yoon Ko, Younghwan Lee, Eunji Kim, Sun Hee Lee, Haneul Kim, Dae Sik Jang#, Jong Hoon Ryu# (2016). Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. Behavioural brain research, 306, 137-145.
- Qingtao Gao, Se Jin Jeon, Hyun Ah Jung, Hyung Eun Lee, Se Jin Park, Younghwan Lee, Younghwa Lee, Sang Yoon Ko, Boseong Kim, Jae Sue Choi, Jong Hoon Ryu# (2015). Nodakenin enhances cognitive function and adult hippocampal neurogenesis in mice. Neurochemical research, 40, 1438-1447.
- Sang Yoon Ko, Hyung Eun Lee, Se Jin Park, Se Jin Jeon, Young Hwan Lee, Bo Seong Kim, Young Hwa Lee, Dae Sik Jang#, Jong Hoon Ryu# (2015). Spinosin, a C-glucosylflavone from zizyphus jujuba var. spinosa, ameliorates Aβ1-42 oligomer-induced memory impairment in mice. Biomolecules & therapeutics, 23(2), 156.
- Se Jin Park, Younghwa Lee, Hee Kyong Oh, Hyung Eun Lee, Younghwan Lee, Sang Yoon Ko, Boseong Kim, Jae Hoon Cheong, Chan Young Shin, Jong Hoon Ryu# (2014). Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice. Neuropharmacology, 86, 49-56.